Every cell in the body has a circadian clock that regulates biochemical and cellular processes such as sleep, body temperature, metabolism, hormone levels, and physiology. Human and mouse models suggest that approximately 50% of protein coding genes display circadian rhythmicity at the transcriptional level. There are more than 170 drug targets among these clock-controlled genes, some of which are acted on by 56 of the top 100 best-selling drugs in the US. There is a high correlation between the advent of circadian disruption through shift work and development of several cancer types as per the data accumulated from animal experimental studies and human epidemiological studies. There is no concrete evidence reported, however, at the cellular and molecular levels for humans.
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