The long-term goal is to translate the general principles of circadian clock that govern cancer prevention and its impact on improving the therapeutic efficacies of current anti-cancer modalities.
- To identify the potential mechanisms regulating carcinogenesis through circadian clock disruption.
- To understand the effect of the circadian clock on skin biology via solar UV-B radiation associated with dermatological perturbations including DNA repair, inflammation, immunosuppression, photo aging, and skin cancer.
- To unravel the molecular basis for chrono pharmacology role in improved efficacy of genotoxic stress mediated cancer therapeutics using breast cancer and melanoma as disease models.
Department of Defense