Research Areas

 

An overview of Circadian Biology

Focus Goals

The long-term goal is to translate the general principles of circadian clock that govern cancer prevention and its impact on improving the therapeutic efficacies of current anti-cancer modalities.

      1. To identify the potential mechanisms regulating carcinogenesis through circadian clock disruption.
      2. To understand the effect of the circadian clock on skin biology via solar UV-B radiation associated with dermatological perturbations including DNA repair, inflammation, immunosuppression, photo aging, and skin cancer.
      3. To unravel the molecular basis for chrono pharmacology role in improved efficacy of genotoxic stress mediated cancer therapeutics using breast cancer and melanoma as disease models.

Funding

NIH

Department of Defense