Shobhan Gaddameedhi

Shobhan Gaddameedhi received his master’s degree in Plant Sciences from the University of Hyderabad, India and PhD in Pharmaceutical Sciences from North Dakota State University (2003-2008). He pursued his post-doctoral training in the circadian biology and DNA repair fields with Prof. Aziz Sancar, at the University of North Carolina Chapel Hill (2008-2014). Before joining as an Associate Professor with tenure as part of the Chancellor’s Faculty Excellence Program in Environmental Health Sciences at North Carolina State University in July 2020, he worked as an Assistant Professor at Washington State University (2014-2020). Dr. Gaddameedhi is a recipient of NIH/NIEHS K99/R00 Career Development Award (2013), DOD/CDMRP Career Development Award (2018), NIH/NIEHS Outstanding New Environmental Scientist/ONES Award (2020). In addition, Dr. Gaddameedhi is a recipient of UNC Postdoctoral Award for Research Excellence (2013), American Society for Photobiology (ASP) New Investigator Award (2018) and Environmental Mutagenesis and Genomics Society (EMGS) Newly Independent Investigator Program Award (2018). Using the cell- and molecular biology approaches with mammalian cell culture, genetic mouse models, and human biopsies, the Gaddameedhi lab is currently focused on three major areas of investigation on human health: (1) unraveling the molecular basis for circadian clock and UV-DNA damage repair roles in environmental health outcomes through ‘gene-environment’ interactions; (2) understanding the mechanistic basis for genomic instability, cardiovascular toxicity, and skin carcinogenesis through circadian disruption by shift work; and (3) understanding the effect of emerging environmental contaminants on circadian rhythmicity, sleep and DNA damage response (DDR) signaling. Overall, the research from Gaddameedhi lab will provide a mechanistic understanding of the biological clock’s role in ‘gene-environment’ interactions and its impact on environmental disease prevention and therapeutic efficacy.